Research
Not Just
Science-Backed:
Science-Led
A lot of brands say they follow the science, but Liquid I.V.®’s expertise, trials and results lead the way in hydration science.
Tear. Pour. Learn more about
- 1.
OUR Trials: How Liquid I.V.® is evolving hydration science
- 2.
OUR results: The numbers that show how well our science works
- 3.
OUR EXPERTS: The experts who make it possible
Electrolytes, vitamins and 12 clinical trials
From an extensive clinical testing program to a Scientific Advisory Board made up of industry-leading experts, discover what goes into creating extraordinary hydration products.
Our Trials
We conduct clinical trials so that we know how–and how well–our product works
We partner with subject matter experts who conduct clinical trials, often using gold-standard, validated methods. This means testing our actual products—not just individual ingredients—on real people who reflect our diverse audience. Surprisingly, not all hydration brands do this: It's time consuming, it's costly, and what happens if your science doesn't hold up?
But Liquid I.V.® sets the industry standard in hydration research in a number of very important ways:
Groundbreaking inclusivity
We aim for the participants in our trials to be representative of a broad population across background, sex and age to ensure our products are effective and relevant for as many people as possible. This also helps to address long-standing gaps in hydration research, in which some groups (like women!) have been underrepresented or ignored completely.
12 completed and ongoing trials
With 12 completed and ongoing trials (and more planned) we ensure we're always at the forefront of the science.
Over $6M invested
To date, we have invested $6 million in hydration research and collaborations with leading universities (with, you guessed it, more planned).
Clinical trials: The details
We use a variety of research approaches to test the effectiveness of our products, including:
Beverage Hydration Index (BHI)
BHI assesses the hydration potential of a drink relative to water when individuals are in a resting and hydrated state. The higher the BHI, the more hydrating the drink.
Exercise-induced dehydration studies
Exercise can have a significant effect on hydration status, so we incorporate it into our studies so they’re more reliable and realistic to real-life.
Pharmacokinetic studies
Tests to understand the rate of absorption of functional ingredients within our science-backed formula.
Real world evidence
Testing real world efficacy by capturing product performance and participant experience in natural settings.
Our Results
There's a whole lot of data behind our hydration claims
We want you to have helpful information to make your hydration choices, and the results of our studies are what lets you hydrate with confidence. Here are the results of the clinical studies behind some of our key product claims:
Fig 01: Liquid I.V.® Hydration Multiplier® and Hydration Multiplier® Sugar-Free
Hydrates faster than water alone
[1][2]Over 30% faster at 3 hours after consumption, in fact. And 30% is a big deal. If you got chased by a bear who ran 30% faster than you, you'd have been eaten by now. And that's nearly as bad as beaing dehydrated.
1Gopalakrishnan ST, Kooima PK, Kavouras IE, et al. Novel allulose amino acid-containing sugar-free beverage results in rapid ad-libitum rehydration following exercise-induced dehydration. Med Sci Sports Exerc. 2025;57:789–790.
2Manuscript in preparation.How We Measure Rehydration
Deuterium is a compound that can be used to measure the speed at which rehydration occurs in the body. This randomized crossover study looked at the rate of deuterium appearance as a marker for fluid absorption. Both Liquid I.V.® Hydration Multiplier® and Hydration Multiplier® Sugar-Free demonstrated consistently faster rehydration rates compared to water alone throughout the rehydration period, indicating rapid rehydration.
Fig 02: Liquid I.V.® Hydration Multiplier® Sugar-Free
Hydrates faster than water alone without raising blood sugar levels
[3]We see you, folks who are watching their blood sugar levels. Spike volleyballs not blood sugar, amirite?
3Gopalakrishnan ST, Kooima PK, Kavouras IE, et al. Allulose-sweetened beverage maintains glycemic stability during post-exercise rehydration in the heat. Med Sci Sports Exerc. 2025;57:789-790.
Plasma Glucose Level
Plasma glucose refers to the amount of glucose (sugar) in your blood plasma. This study showed Liquid I.V.® Hydration Multiplier® Sugar-Free does not raise blood sugar levels over time after consumption.
Water
Liquid I.V.® Hydration Multiplier® Sugar-Free
Fig. 03: Liquid I.V.® Hydration Multiplier® and Hydration Multiplier® Sugar-Free
CLINICALLY DEMONSTRATED TO HELP YOU STAY HYDRATED LONGER THAN WATER ALONE
[4]This shows that we can help you stay more hydrated for up to four hours. On a slow Sunday, that could be enough time to binge-watch a couple of your favorite movies. Trust us, we’ve done it.
4Bloomer R, Lelko M, et al. Oral rehydration solutions improve measures of hydration over a 4-hour period in healthy men and women. Curr Dev Nutr. 2025;9:106656.
Beverage Hydration Index (BHI)
This randomized, single-blind, crossover study showed Liquid I.V.® Hydration Multiplier® and Hydration Multiplier® Sugar-Free helped the body retain more fluid for up to four hours compared to water alone.
Our Experts
Meet The Team
Liquid I.V.®’s science teams are made up of qualified experts with deep knowledge across exercise physiology, food science and nutrition. We have also appointed a Scientific Advisory Board including world-renowned hydration experts to guide our research and strategy.
Dana Ryan
PhD, MBA, MA | Senior Director, Scientific Affairs, Liquid I.V.® & Chair of the Board
Dana Ryan
Dr. Ryan oversees a robust clinical trial pipeline, novel ingredient innovation, and the research program at Liquid I.V. With experience in both academic and corporate positions, Dana is a hydration science expert who leads innovative, science-first strategies for both industry professionals and general consumers.
Stavros Kavouras
PhD, FNAK, FACSM, FECSS | Scientific Advisory Board Member
Stavros Kavouras
Dr. Kavouras is an Assistant Dean of Graduate Education for the College of Health Solutions at Arizona State University. He is also the founding director of the Hydration Science Lab, author of over 170 peer-reviewed articles and has been cited more than 13,000 times.
Richard Bloomer
PhD | Scientific Advisory Board Member
Richard Bloomer
Professor Bloomer is Dean of the College of Health Sciences at the University of Memphis. He founded the Center for Nutraceutical and Dietary Supplement Research, has secured funding for over 70 research projects, and has author credits on more than 200 peer-reviewed scientific manuscripts and book chapters.
Adrian Chavez
PHD | Scientific Advisory Board Member
Adrian Chavez
Dr. Chavez is a scientist, educator, and consultant dedicated to making evidence-based health information accessible. He holds degrees in Exercise Science, a doctorate in Nutrition and Health Promotion, and hosts “The Nutrition Science Podcast” that delivers science-based insights on nutrition.
Stuart Phillips
PhD, FACSM, FCAHS | Scientific Advisory Board Member
Stuart Phillips
Dr. Phillips is a Distinguished University Professor in the Department of Kinesiology and a member of the School of Medicine at McMaster University. He is also a Tier 1 Canada Research Chair in Skeletal Muscle Health and was recently appointed as a Fellow of the Royal Society of Canada (FRSC).
Marie A. Spano
MS, RD, CSCS, CSSD | Scientific Advisory Board Member
Marie A. Spano
Marie is one of the country’s leading sports nutritionists, combining science with practical experience to help athletes maximize performance. She works with the Washington Nationals and Atlanta Hawks, and previously worked with the Chicago Cubs, Atlanta Falcons, Atlanta Thrashers, Blackzillians MMA, and the Atlanta Braves.
Connor Spencer
MS | Scientific Advisory Board Member
Connor Spencer
Connor has been Los Angeles Football Club’s Performance Nutritionist since 2022, having previously worked in collegiate team sports, endurance cycling and triathlon. He is passionate about promoting recovery and preparation, and holds a master’s degree in Sports Nutrition from Liverpool John Moores University.
Sai Chaluvadi
PhD | Chief of R&D,
Liquid I.V.Sai Chaluvadi
Dr. Chaluvadi leads Liquid I.V.’s R&D organization, with a mission to push the boundaries of flavor and function in hydration. He earned his doctorate in Food Science from Rutgers University and conducted research at the U.S. Department of Agriculture before moving into industry leadership.
Scientists in the wild
In the same way that our hydration science is real-life ready, our hydration scientists don't just stay in the lab. Check out the list of conferences where our thought-leaders appeared in person in 2025, and stay posted for updates on where to catch them in 2026.
Conference
Date
Title
American College of Sports Medicine Annual Meeting
5.27 — 5.30
5.27 — 5.30
Hydration Status with Caffeinated Beverages Versus Water: Does Habitual Caffeine Intake Matter?
American College of Sports Medicine Annual Meeting
5.27 — 5.30
5.27 — 5.30
Novel Allulose Amino-Acid Containing Sugar-Free Beverage Results in Rapid Ad-Libitum Rehydration Following Exercise-Induced Dehydration
American Society for Nutrition Annual Meeting
5.31 — 6.3
5.31 — 6.3
Oral Rehydration Solutions Improve Measures of Hydration Over a 4hr Period in Healthy Men and Women
European College of Sport Science Annual Congress
7.1 — 7.4
7.1 — 7.4
Impact of Caffeine and Electrolyte Level on Measures of Hydration Over a 4hr Period in Healthy Men and Women
Food and Nutrition Conference and Expo
10.11 — 10.14
10.11 — 10.14
Allulose-Based ORS Supports Effective Rehydration Without Increasing Plasma Glucose
Sip the science
for yourself
By far the tastiest way to consume over a decade worth of hydration expertise. In our opinion.